Relationship between disorders of the intestinal microbiota and heart failure in infants with congenital heart disease.

ABSTRACT:

Purpose

There is a close relationship between the intestinal microbiota and heart failure, but no study has assessed this relationship in infants with congenital heart disease. This study aimed to explore the relationship between heart failure and intestinal microbiota in infants with congenital heart disease.

Methods

Twenty-eight infants with congenital heart disease with heart failure admitted to a provincial children's hospital from September 2021 to December 2021 were enrolled in this study. A total of 22 infants without heart disease and matched for age, sex, and weight were selected as controls. Faecal samples were collected from every participant and subjected to 16S rDNA gene sequencing.

Results

The composition of the intestinal microbiota was significantly di

SUBMITTER: Zhang QL 

PROVIDER: S-EPMC10036851 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature