Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates.

ABSTRACT: The transplanting islets to the liver approach suffers from an immediate posttransplant loss of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery of grafts should there be serious complications such as the development of teratomas with grafts that are stem cell-derived islets (SC-islets). The omentum features an attractive extrahepatic alternative site for clinical islet transplantation. We explore an approach in which allogeneic islets are transplanted onto the omentum, which is bioengineered with a plasma-thrombin biodegradable matrix in three diabetic non-human primates (NHPs). Within 1 week posttransplant, each transplanted NHP achieves normoglycemia and insulin independence and remains stable until termination of the experiment. Success was achie

SUBMITTER: Deng H 

PROVIDER: S-EPMC10040375 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature