Hepatitis C virus fitness can influence the extent of infection-mediated epigenetic modifications in the host cells.

ABSTRACT:

Introduction

Cellular epigenetic modifications occur in the course of viral infections. We previously documented that hepatitis C virus (HCV) infection of human hepatoma Huh-7.5 cells results in a core protein-mediated decrease of Aurora kinase B (AURKB) activity and phosphorylation of Serine 10 in histone H3 (H3Ser10ph) levels, with an affectation of inflammatory pathways. The possible role of HCV fitness in infection-derived cellular epigenetic modifications is not known.

Methods

Here we approach this question using HCV populations that display a 2.3-fold increase in general fitness (infectious progeny production), and up to 45-fold increase of the exponential phase of intracellular viral growth rate, relative to the parental HCV population.

Results

We show that inf

SUBMITTER: Garcia-Crespo C 

PROVIDER: S-EPMC10040758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature