Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis.

ABSTRACT: The process of adipogenesis involves the differentiation of preadipocytes into mature adipocytes. Excessive adipogenesis promotes obesity, a condition that increasingly threatens global health and contributes to the rapid rise of obesity-related diseases. We have recently shown that prenylcysteine oxidase 1 (PCYOX1) is a regulator of atherosclerosis-disease mechanisms, which acts through mechanisms not exclusively related to its pro-oxidant activity. To address the role of PCYOX1 in the adipogenic process, we extended our previous observations confirming that Pcyox1^-/-/Apoe^-/- mice fed a high-fat diet for 8 or 12 weeks showed significantly lower body weight, when compared to Pcyox1^+/+/Apoe^-/- mice, due to an evident reduction in visceral adipose

SUBMITTER: Banfi C 

PROVIDER: S-EPMC10045348 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature