GENLIB: new function to simulate haplotype transmission in large complex genealogies.

ABSTRACT:

Summary

Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.

Availability and implementation

The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.

SUBMITTER: Rakesh M 

PROVIDER: S-EPMC10049784 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature