Effects of the 5-HT_2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents.

ABSTRACT:

Background

Clinical studies suggest that psychedelics exert robust therapeutic benefits in a number of psychiatric conditions including substance use disorder. Preclinical studies focused on safety and efficacy of these compounds are necessary to determine the full range of psychedelics' effects.

Objectives

The present study explores the behavioral pharmacology of structurally distinct psychedelics in paradigms associated with serotonin 2A receptor (5-HT_2AR) activation and behavioral disruption in two rodent models. Utilizing the selective 5-HT_2AR antagonist volinanserin, we aimed to provide further pharmacological assessment of psychedelic effects in rodents.

Methods

We compared volinanserin (0.0001-0.1 mg/kg) antagonism of the phenethylamine 1-

SUBMITTER: Jaster AM 

PROVIDER: S-EPMC10055857 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature