Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress.

ABSTRACT:

Background

Early-life stress (ELS) affects brain development and increases the risk of mental disorders associated with the dysfunction of the medial prefrontal cortex (mPFC). The mechanisms of ELS action are not well understood. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are cellular processes involved in brain maturation through the regulation of pro-survival or proapoptotic processes. We hypothesized that ER stress and the UPR in the mPFC are involved in the neurobiology of ELS.

Methods

We performed a maternal separation (MS) procedure from postnatal days 1 to 14 in rats. Before each MS, pups were injected with an inhibitor of ER stress, salubrinal or a vehicle. The mRNA and protein expression of UPR and apoptotic markers were evaluated in t

SUBMITTER: Solarz-Andrzejewska A 

PROVIDER: S-EPMC10060333 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature