Pinpointing the precise stimulation targets for brain rehabilitation in early-stage Parkinson's disease.

ABSTRACT:

Background

Transcranial magnetic stimulation (TMS) is increasingly used as a promising non-pharmacological treatment for Parkinson's disease (PD). Scalp-to-cortex distance (SCD), as a key technical parameter of TMS, plays a critical role in determining the locations of treatment targets and corresponding dosage. Due to the discrepancies in TMS protocols, the optimal targets and head models have yet to be established in PD patients.

Objective

To investigate the SCDs of the most popular used targets in left dorsolateral prefrontal cortex (DLPFC) and quantify its impact on the TMS-induced electric fields (E-fields) in early-stage PD patients.

Methods

Structural magnetic resonance imaging scans from PD patients (n = 47) and normal controls (n = 36) were drawn from the NEU

SUBMITTER: Lu H 

PROVIDER: S-EPMC10061909 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature