An ultra-high-throughput screen for the evaluation of peptide HLA-Binder interactions.
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ABSTRACT:
SUBMITTER: Kramer S
PROVIDER: S-EPMC10066226 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
An ultra-high-throughput screen for the evaluation of peptide HLA-Binder interactions.
Krämer Stefan S Moritz Andreas A Stehl Luca L Hutt Meike M Hofmann Martin M Wagner Claudia C Bunk Sebastian S Maurer Dominik D Roth Günter G Wöhrle Johannes J
Scientific reports 20230331 1
Peptide human leukocyte antigen (pHLA) targeting therapeutics like T-cell receptor based adoptive cell therapy or bispecific T cell engaging receptor molecules hold great promise for the treatment of cancer. Comprehensive pre-clinical screening of therapeutic candidates is important to ensure patient safety but is challenging because of the size of the potential off-target space. By combining stabilized peptide-receptive HLA molecules with microarray printing and screening, we have developed an ...[more]
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