Perspectives of diverse Spanish- and English-speaking patients on the clinical use of polygenic risk scores.

ABSTRACT:

Purpose

As polygenic risk scores (PRS) emerge as promising tools to inform clinical care, there is a pressing need for patient-centered evidence to guide their implementation, particularly in diverse populations. Here, we conducted in-depth interviews of diverse Spanish- and English-speaking patients to explore their perspectives on clinical PRS.

Methods

We enrolled 30 biobank participants aged 35-50 years through a purposive sampling strategy, ensuring that >75% self-reported as African/African American or Hispanic/Latinx and half were Spanish-speaking. Semistructured interviews in Spanish or English explored attitudes toward PRS, barriers to adoption, and communication preferences. Data were analyzed using an inductive thematic analysis approach.

Results

Perceived u

SUBMITTER: Suckiel SA 

PROVIDER: S-EPMC10066541 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature