Serum cholesterol and the risk of developing hormonally driven cancers: A narrative review.

ABSTRACT: Although cholesterol has been hypothesized to promote cancer development through several potential pathways, its role in the risk of developing hormonally driven cancer is controversial. This literature review summarizes evidence from the highest quality studies to examine the consistency and strength of the relationship between serum cholesterol parameters and incidence of hormonally driven cancer. Articles were identified using EMBASE. Longitudinal observational studies published between January 2000 and December 2020 were considered for inclusion. The endpoint of interest was incident prostate, ovary, breast, endometrium, and uterine cancers. In total, 2732 reports were identified and screened; 41 studies were included in the review. No associations were found for ovarian cancer. Most e

SUBMITTER: Murdock DJ 

PROVIDER: S-EPMC10067100 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature