Proton therapy for adult craniopharyngioma: Experience of a single institution in 91 consecutive patients.

ABSTRACT:

Background

Craniopharyngioma (CP) in adults is a rare benign tumor associated with many morbidities, with limited contemporary studies to define treatment, and follow-up guidelines.

Methods

A single-center retrospective study was conducted on patients aged ≥ 18 years from 2006-2018 with CP and who were treated with proton therapy (PT). Late toxicity was defined as a minimum of 18 months from diagnosis. Overall survival (OS), local recurrence-free survival (LRFS), and toxicity were characterized using Kaplan-Meier and Cox regression analyses.

Results

Ninety-one patients met the criteria, with a median age of 37 years (range 18-82 years). PT was conducted after tumor resection in 88 patients (97%), in 64 patients (70.3%) as an adjuvant strategy and in 27 (29.7%) after r

SUBMITTER: Beddok A 

PROVIDER: S-EPMC10076942 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature