Midlife lipid and glucose levels are associated with Alzheimer's disease.

ABSTRACT:

Introduction

It is unknown whether vascular and metabolic diseases assessed in early adulthood are associated with Alzheimer's disease (AD) later in life.

Methods

Association of AD with lipid fractions, glucose, blood pressure, body mass index (BMI), and smoking obtained prospectively from 4932 Framingham Heart Study (FHS) participants across nine quadrennial examinations was evaluated using Cox proportional hazard and Kaplan-Meier models. Age-, sex-, and education-adjusted models were tested for each factor measured at each exam and within three adult age groups (early = 35-50, middle = 51-60, and late = 61-70).

Results

A 15 mg/dL increase in high density lipoprotein (HDL) cholesterol was associated with decreased AD risk during early (15.4%, P = 0.041) and middle (1

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10078665 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature