Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma.

ABSTRACT:

Purpose

Asthma is a frequent chronic inflammatory bronchial disease affecting more than 300 million patients worldwide, 70% of whom are secondary to allergy. The diversity of asthmatic endotypes contributes to their complexity. The inter-relationship between allergen and other exposure and the airway microbiome adds to the phenotypic diversity and defines the natural course of asthma. Here, we compared the mouse models of house dust mite (HDM)-induced allergic asthma. Allergic sensitization was performed via various routes and associated with outcomes.

Methods

Mice were sensitized with HDM via the oral, nasal or percutaneous routes. Lung function, barrier integrity, immune response and microbiota composition were analyzed.

Results

Severe impairment of respiratory func

SUBMITTER: Dijoux E 

PROVIDER: S-EPMC10079520 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature