Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.

ABSTRACT: Despite the recent emergence of multiple cellular and molecular strategies to restore vision in retinal disorders, it remains unclear to what extent central visual circuits can recover when retinal defects are corrected in adulthood. We addressed this question in an Lrat^-/- mouse model of Leber congenital amaurosis (LCA) in which retinal light sensitivity and optomotor responses are partially restored by 9-cis-retinyl acetate administration in adulthood. Following treatment, two-photon calcium imaging revealed increases in the number and response amplitude of visually responsive neurons in the primary visual cortex (V1). In particular, retinoid treatment enhanced responses from the ipsilateral eye, restoring the normal balance of eye-specific responses in V1. Additionally, the t

SUBMITTER: Huh CYL 

PROVIDER: S-EPMC10083103 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature