Chromosomal abnormalities detected by karyotyping among patients with secondary amenorrhea: a retrospective study.

ABSTRACT:

Background

Chromosomal abnormalities (CAs) have been described in patients with secondary amenorrhea (SA). However, studies on this association are scarce.

Objectives

To evaluate the frequency and types of CAs detected by karyotyping in patients with SA.

Design and setting

This retrospective study was performed in a reference clinical genetic service in South Brazil.

Methods

Data were obtained from the medical records of patients with SA who were evaluated between 1975 and 2022. Fisher's bicaudate exact test and Student's t-test were used, and P < 0.05 was considered significant.

Results

Among 43 patients with SA, 14 (32.6%) had CAs, namely del (Xq) (n = 3), 45,X (n = 2), 46,X,r(X)/45,X (n = 2), 46,XX/45,X (n = 1), 46,X,i(q10)/45,X (n = 1), 47,XXX (n = 1

SUBMITTER: Besson MDR 

PROVIDER: S-EPMC10085534 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature