PD-L1^ATTAC mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy.

ABSTRACT: Antibodies targeting the PD-1 receptor and its ligand PD-L1 have shown impressive responses in some tumors of bad prognosis. We hypothesized that, since immunosuppressive cells might present several immune checkpoints on their surface, the selective elimination of PD-L1 expressing cells could be efficacious in enabling the activation of antitumoral immune responses. To address this question, we developed an inducible suicidal knock-in mouse allele of Pd-l1 (PD-L1^ATTAC) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues. Consistent with our hypothesis, elimination of PD-L1 expressing cells from the mouse peritoneum increased the septic response to lipopolysaccharide (LPS), due to an exacerbated inflammatory response to the end

SUBMITTER: Fueyo-Marcos E 

PROVIDER: S-EPMC10085585 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature