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A biomimetic piezoelectric scaffold with sustained Mg²⁺ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

ABSTRACT: Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatment and sustained release of magnesium ion (Mg²⁺). Herein, a composite scaffold (denoted as PWH scaffold) composed of piezoelectric WH (PWH) and poly(ε-caprolactone) (PCL) was 3D printed to meet the physiological demands for the regeneration of neuro-vascularized bone tissue, namely, providing endogenous electric field at the defect site. The sustained release of Mg²⁺ from the PWH scaffold, displaying multiple biological activities, and thus exhibits a strong synergistic effect with the piezoelectricity on inhibiting osteoclast activation, promoting the neurogenic, angiogenic, and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) in vitro. In a rat calvarial defect model, this PWH scaffold is remarkably conducive to efficient neo-bone formation with rich neurogenic and angiogenic expressions. Overall, this study presents the first example of biomimetic piezoelectric scaffold with sustained Mg²⁺ release for promoting the regeneration of neuro-vascularized bone tissue in vivo, which offers new insights for regenerative medicine.

SUBMITTER: Wang L

PROVIDER: S-EPMC10087109 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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A biomimetic piezoelectric scaffold with sustained Mg<sup>2+</sup> release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

Wang Liangyu L Pang Yanyun Y Tang Yujing Y Wang Xinyu X Zhang Daixing D Zhang Xu X Yu Yingjie Y Yang Xiaoping X Cai Qing Q

Bioactive materials 20221129

Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatment and sustained release of magnesium ion (Mg<sup>2+</sup>). Herein, a composite scaffold (denoted as PWH scaffold) composed of piezoelectric WH (PWH) and poly(ε-caprolactone) (PCL) was 3D printed to ...[more]

PMID: 37056250

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A biomimetic piezoelectric scaffold with sustained Mg²⁺ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

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A biomimetic piezoelectric scaffold with sustained Mg<sup>2+</sup> release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

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A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

Publications

A biomimetic piezoelectric scaffold with sustained Mg<sup>2+</sup> release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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A biomimetic piezoelectric scaffold with sustained Mg²⁺ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration.