Nickel allergy is associated with a broad spectrum cytokine response.

ABSTRACT:

Background

Nickel-induced proliferation or cytokine release by peripheral blood mononuclear cells may be used for in vitro diagnosis of nickel allergy.

Objectives

Aim of this study was to explore the nickel-specific cytokine profile to further elucidate the pathogenesis of nickel allergic contact dermatitis (ACD) and to identify potential new biomarkers for nickel ACD.

Methods

Peripheral blood mononuclear cells from patients and controls were cultured with T-cell skewing cytokine cocktails and/or nickel. Cytokine and chemokine concentrations were assessed in culture supernatants using validated multiplex assays. Specific cytokine production was related to history of nickel allergy and patch-test results.

Results

Twenty-one of the 33 analytes included in the ana

SUBMITTER: De Graaf NPJ 

PROVIDER: S-EPMC10087880 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature