Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents.

ABSTRACT:

Introduction

Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.

Methods

Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.

Results

Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8

SUBMITTER: Cheng PN 

PROVIDER: S-EPMC10091014 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature