Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study.

ABSTRACT:

Background

Oxygen supply to the brain is of special importance during intracranial surgery because it may be compromised by intracranial pathology. A high arterial blood pressure (mean arterial pressure above 80 mmHg) and a high arterial oxygen tension (PaO₂ above 12 kPa) is therefore often targeted in these patients, when for example intracranial pressure is increased or when a mass effect on brain tissue from a tumour is present, and it is pursued by administering vasopressors such as phenylephrine and by increasing inspiratory oxygen fraction (FiO₂ ). However, whether these interventions increase cerebral oxygenation remains uncertain. We aimed to investigate the effect of hyperoxia and phenylephrine on brain tissue oxygen tension (PbtO₂ ) in pat

SUBMITTER: Pedersen SS 

PROVIDER: S-EPMC10092244 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature