Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism.

ABSTRACT:

Background

High consumption of Annona muricata fruit has been previously identified as a risk factor for atypical parkinsonism in the French Caribbean islands.

Objective

We tested whether consumption of Annonaceae products could worsen the clinical phenotype of patients with any form of degenerative parkinsonism.

Methods

We analyzed neurological data from 180 Caribbean parkinsonian patients and specifically looked for dose effects of lifelong, cumulative Annonaceae consumption on cognitive performance. Using unsupervised clustering, we identified one cluster with mild/moderate symptoms (N = 102) and one with severe symptoms including cognitive impairment (N = 78).

Results

We showed that even low cumulative consumption of fruits/juices (>0.2 fruit-years) or any

SUBMITTER: Cleret de Langavant L 

PROVIDER: S-EPMC10092620 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature