Dataset Information

Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort.

ABSTRACT:

Aims

People with pre-diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre-diabetes.

Methods

A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre-diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazards regression was used to calculate adjusted hazard rate ratios (aHR) for the risk of progression from pre-diabetes to type 2 diabetes for each of the exposure categories [ethnicity, deprivation (Townsend), age and body mass index (BMI)] separately.

Results

Of the baseline population with pre-diabetes (n = 397,853), South Asian (aHR 1.31; 95% CI 1.26-1.37) or Mixed-Race individuals (aHR 1.22; 95% CI 1.11-1.33) had an increased risk of progression to type 2 diabetes compared with those of white European ethnicity. Likewise, deprivation (aHR 1.17; 95% CI 1.14-1.20; most vs. least deprived) was associated with an increased risk of progression. Both younger (aHR 0.63; 95% CI 0.58-0.69; 18 to <30 years) and older individuals (aHR 0.85; 95% CI 0.84-0.87; ≥65 years) had a slower risk of progression from pre-diabetes to type 2 diabetes, than middle-aged (40 to <65 years) individuals.

Conclusions

South Asian or Mixed-Race individuals and people with social deprivation had an increased risk of progression from pre-diabetes to type 2 diabetes. Clinicians need to recognise the differing risk across their patient populations to implement appropriate prevention strategies.

SUBMITTER: Gardner MP

PROVIDER: S-EPMC10099224 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort.

Gardner Michael P MP Wang Jingya J Hazlehurst Jonathan M JM Sainsbury Chris C Blissett Jacqueline J Nirantharakumar Krishnarajah K Thomas Neil N Bellary Srikanth S

Diabetic medicine : a journal of the British Diabetic Association 20221111 3

<h4>Aims</h4>People with pre-diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre-diabetes.<h4>Methods</h4>A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre-diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazard ...[more]

PMID: 36308066

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Dataset Information

Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort.

Aims

Methods

Results

Conclusions

Publications

Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort.

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