A feasibility study of perioperative vitamin D supplementation in patients undergoing colorectal cancer resection.

ABSTRACT:

Background

Vitamin D supplementation improves colorectal cancer (CRC) survival outcomes in randomized trials. The aim of this study was to test the feasibility, safety and efficacy of vitamin D supplementation in the pre- and perioperative period in patients undergoing CRC surgery.

Methods

Patients were given 3200IU oral cholecalciferol (D3) per day perioperatively. Serial serum 25-hydroxyvitamin (25OHD) was measured by liquid chromatography tandem mass spectrometry and compared to untreated CRC controls. 25OHD and C-reactive protein (CRP) levels were compared using adjusted generalized linear mixed-effects models.

Results

A total of 122 patients underwent serial perioperative sampling, including 41 patients given high-dose perioperative supplementation. Supplementati

SUBMITTER: Vaughan-Shaw PG 

PROVIDER: S-EPMC10103841 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature