Nutritional Formulation for Patients with Angelman Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study of Exogenous Ketones.

ABSTRACT:

Background

Angelman syndrome (AS) patients often respond to low glycemic index therapy to manage refractory seizures. These diets significantly affect quality of life and are challenging to implement. These formulations may have benefits in AS even in the absence of biomarkers suggesting ketosis.

Objectives

We aimed to compare an exogenous medical food ketone formulation (KF) with placebo for the dietary management of AS.

Methods

This randomized, double-blind, placebo-controlled, crossover clinical trial was conducted in an academic center from 15 November, 2018 to 6 January, 2020. Thirteen participants with molecularly confirmed AS aged 4-11 y met the criteria and completed the 16-wk study. The study consisted of four 4-wk phases: a baseline phase, a blinded KF or pl

SUBMITTER: Carson RP 

PROVIDER: S-EPMC10103907 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature