Genetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.

ABSTRACT:

Introduction

Selenium is a trace mineral that is commonly included in micronutrient supplements. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its association with estimated glomerular filtration rate (eGFR) can be used to assess the causal estimates by Mendelian randomization (MR).

Methods

In this MR study, we instrumented 11 genetic variants associated with blood or total selenium levels from a previous genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the chronic kidney disease(CKDGen) GWAS meta-analysis summary statistics, including 567,460 European samples. Inverse-variance weighted and pleiotropy-robust MR an

SUBMITTER: Park S 

PROVIDER: S-EPMC10105058 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature