Toll-like receptors control the accumulation of neutrophils in lymph nodes that expand CD4⁺ T cells during experimental autoimmune encephalomyelitis.

ABSTRACT: Toll-like receptors (TLR) control the activation of dendritic cells that prime CD4⁺ T cells in draining lymph nodes, where these T cells then undergo massive clonal expansion. The mechanisms controlling this clonal T cell expansion are poorly defined. Using the CD4⁺ T cell-mediated disease experimental autoimmune encephalomyelitis (EAE), we show here that this process is markedly suppressed when TLR9 signaling is increased, without noticeably affecting the transcriptome of primed T cells, indicating a purely quantitative effect on CD4⁺ T cell expansion. Addressing the underpinning mechanisms revealed that CD4⁺ T cell expansion was preceded and depended on the accumulation of neutrophils in lymph nodes a few days after immunization. Underlying the

SUBMITTER: Shen P 

PROVIDER: S-EPMC10107244 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature