Prediction of perinatal survival in early-onset fetal growth restriction: role of placental growth factor.

ABSTRACT:

Objective

To analyze the ability to predict perinatal survival and severe neonatal morbidity of cases with early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters and angiogenic markers at the time of diagnosis.

Methods

This was a prospective observational study in a cohort of singleton pregnancies with a diagnosis of eoFGR (< 32 weeks of gestation). At diagnosis of eoFGR, complete assessment was performed, including ultrasound examination (anatomy, biometry and Doppler assessment) and maternal serum measurement of the angiogenic biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). Logistic regression models for the prediction of perinatal survival (in cases diagnosed at < 28 weeks) and severe neonat

SUBMITTER: Rodriguez-Calvo J 

PROVIDER: S-EPMC10107431 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature