Chronic alcohol administration alters metabolomic profile of murine bone marrow.

ABSTRACT:

Introduction

People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD⁺ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response.

Methods

We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography-coupled mass spectrometry (GC-MS).

Results

We iden

SUBMITTER: Pontes Pereira TT 

PROVIDER: S-EPMC10113543 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature