Prognostic value of perineural invasion in resected non-small cell lung cancer: A meta-analysis.

ABSTRACT:

Objective

The prognostic role of perineural invasion (PNI) in resected non-small cell lung cancer (NSCLC) remains unclear. A meta-analysis was performed to compare the overall survival (OS) of patients with resected NSCLC with and without PNI.

Methods

The PubMed, EMBASE, and Web of Science databases were systematically searched to identify relevant studies investigating the effect of PNI on OS in patients with resected NSCLC. Pooled hazard ratio (HR) and 95% confidence intervals (CI) were estimated using a random-effects model. Separate meta-analyses using adjusted or unadjusted HR for OS were performed using Stata/SE 12.0.

Results

Eleven studies comprising 2,279 patients were included. In total, PNI was identified in 9% (median, 4%-31%) of patients with resected NSCL

SUBMITTER: Liu W 

PROVIDER: S-EPMC10113867 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature