Comparison of gadolinium-based contrast agents for MR cholangiography in saline, blood and bile: a phantom study.

ABSTRACT:

Background

We compared T1- and T2-weighted signal intensities of liver-specific (gadoxetate, gadobenate) and non-specific (gadoterate) gadolinium contrast agents (CAs) in a bile phantom.

Methods

In a phantom study, gadoxetate, gadobenate, and gadoterate were diluted in saline, blood, and bile at different concentrations (0, 0.25, 0.5. 1, 2.5, 5, 10, and 25 mM) and imaged in a 3-T magnetic resonance imaging (MRI) system using T1- and T2-weighted sequences. The maximum signal intensities of CAs were compared for each sequence separately and across all T1-weighted sequences using one-way ANOVA.

Results

Using T1-weighted sequences, CA concentration-dependent signal intensity increase was followed by decrease due to T2* effects. Comparing CAs for each sequence in bile yiel

SUBMITTER: Froehlich JM 

PROVIDER: S-EPMC10126166 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature