Chromobacterium Biopesticide Exposure Does Not Select for Resistance in Aedes Mosquitoes.

ABSTRACT: Developing effective tools to control mosquito populations is essential for reducing the incidence of diseases like malaria and dengue. Biopesticides of microbial origin are a rich, underexplored source of mosquitocidal compounds. We previously developed a biopesticide from the bacterium Chromobacterium sp. Panama that rapidly kills vector mosquito larvae, including Aedes aegypti and Anopheles gambiae. Here, we demonstrate that two independent Ae. aegypti colonies exposed to a sublethal dose of that biopesticide over consecutive generations persistently exhibited high mortality and developmental delays, indicating that resistance did not develop during the study period. Critically, the descendants of biopesticide-exposed mosquitoes experienced decreased longevity and did not display increa

SUBMITTER: Engdahl CS 

PROVIDER: S-EPMC10127667 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature