Estimated sdLDL-C for predicting high-risk coronary plaque features in psoriasis: a prospective observational study.

ABSTRACT:

Background

Psoriasis (PSO) is a skin disorder with systemic inflammation and high coronary artery disease risk. A distinct lipid phenotype occurs in psoriasis, which is characterized by high plasma triglycerides (TGs) with typically normal or even low LDL-C. The extent to which cholesterol on LDL subfractions, such as small dense LDL-C (sdLDL-C), are associated with vulnerable coronary plaque characteristics in PSO remains elusive.

Methods

A recently developed equation for estimating sdLDL-C from the standard lipid panel was utilized in a PSO cohort (n = 200) with 4-year follow-up of 75 subjects. Coronary plaque burden was assessed by quantitative coronary computed tomography angiography (CCTA). Multivariate regression analyses were used for establishing associations and pro

SUBMITTER: Sorokin AV 

PROVIDER: S-EPMC10134516 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature