Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized ¹³C-Pyruvate MRI.

ABSTRACT: Metabolite-specific echo-planar imaging (EPI) sequences with spectral-spatial (spsp) excitation are commonly used in clinical hyperpolarized [1-¹³C]pyruvate studies because of their speed, efficiency, and flexibility. In contrast, preclinical systems typically rely on slower spectroscopic methods, such as chemical shift imaging (CSI). In this study, a 2D spspEPI sequence was developed for use on a preclinical 3T Bruker system and tested on in vivo mice experiments with patient-derived xenograft renal cell carcinoma (RCC) or prostate cancer tissues implanted in the kidney or liver. Compared to spspEPI sequences, CSI were found to have a broader point spread function via simulations and exhibited signal bleeding between vasculature and tumors in vivo. Parameters for the spspEPI se

SUBMITTER: Sahin SI 

PROVIDER: S-EPMC10143874 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature