Semi-quantitative analysis of visually normal ¹²³I-FP-CIT across three large databases revealed no difference between control and patients.

ABSTRACT:

Background

To show the equivalence between the specific binding ratios (SBR) of visually normal ¹²³I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to allow their use as a reference database.

Methods

The SBR values of visually normal SPECT scans from 3 groups were studied: (1) suspected Parkinsonism and no diagnostic follow-up (ScanOnlyDB: n = 764, NM/CT 670 CZT, GE Healthcare), (2) no degenerative dopaminergic pathology after a 5-year follow-up (NoDG5YearsDB: n = 237, Symbia T2, Siemens Medical Solutions), and 3) Hv (HvDB: n = 118, commercial GE database). A general linear model (GLM) was constructed with caudate, putamen, and striatum SBR as the dependent variables, and age and gender as the i

SUBMITTER: Flaus A 

PROVIDER: S-EPMC10147889 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature