Cerebral blood flow velocity progressively decreases with increasing levels of verticalization in healthy adults. A cross-sectional study with an observational design.

ABSTRACT:

Background

Autoregulation of the cerebral vasculature keeps brain perfusion stable over a range of systemic mean arterial pressures to ensure brain functioning, e.g., in different body positions. Verticalization, i.e., transfer from lying (0°) to upright (70°), which causes systemic blood pressure drop, would otherwise dramatically lower cerebral perfusion pressure inducing fainting. Understanding cerebral autoregulation is therefore a prerequisite to safe mobilization of patients in therapy.

Aim

We measured the impact of verticalization on cerebral blood flow velocity (CBFV) and systemic blood pressure (BP), heart rate (HR) and oxygen saturation in healthy individuals.

Methods

We measured CBFV in the middle cerebral artery (MCA) of the dominant hemisphere in 20 subje

SUBMITTER: Deseoe J 

PROVIDER: S-EPMC10149656 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature