Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.

ABSTRACT:

Background

Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand discovery of new genetic loci associated with VTE by using cross-ancestry genomic resources.

Methods

We present new cross-ancestry meta-analyzed GWAS results involving up to 81 669 VTE cases from 30 studies, with replication of novel loci in independent populations and loci characterization through in silico genomic interrogations.

Results

In our genetic discovery effort that included

SUBMITTER: Thibord F 

PROVIDER: S-EPMC10152894 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature