A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression.

ABSTRACT: Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing speed and higher persistence. As a biologically relevant example, we focused on Golgi fragmentation, a phenomenon often linked to alterations of cell migration. Golgi fragmentation was induced by depletion of Giantin, a Golgi matrix protein, the downregulation of which correlates with poor patient survival. Applying the experimentally obtained migration and invasion traits of Giantin depleted br

SUBMITTER: Ghannoum S 

PROVIDER: S-EPMC10159355 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature