MultiCens: Multilayer network centrality measures to uncover molecular mediators of tissue-tissue communication.

ABSTRACT: With the evolution of multicellularity, communication among cells in different tissues and organs became pivotal to life. Molecular basis of such communication has long been studied, but genome-wide screens for genes and other biomolecules mediating tissue-tissue signaling are lacking. To systematically identify inter-tissue mediators, we present a novel computational approach MultiCens (Multilayer/Multi-tissue network Centrality measures). Unlike single-layer network methods, MultiCens can distinguish within- vs. across-layer connectivity to quantify the "influence" of any gene in a tissue on a query set of genes of interest in another tissue. MultiCens enjoys theoretical guarantees on convergence and decomposability, and performs well on synthetic benchmarks. On human multi-tissue datase

SUBMITTER: Kumar T 

PROVIDER: S-EPMC10159362 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature