Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC10167347 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
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Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape.
Li Qing Q Chen Jieyi J Faux Pierre P Delgado Miguel Eduardo ME Bonfante Betty B Fuentes-Guajardo Macarena M Mendoza-Revilla Javier J Chacón-Duque J Camilo JC Hurtado Malena M Villegas Valeria V Granja Vanessa V Jaramillo Claudia C Arias William W Barquera Rodrigo R Everardo-Martínez Paola P Sánchez-Quinto Mirsha M Gómez-Valdés Jorge J Villamil-Ramírez Hugo H Silva de Cerqueira Caio C CC Hünemeier Tábita T Ramallo Virginia V Wu Sijie S Du Siyuan S Giardina Andrea A Paria Soumya Subhra SS Khokan Mahfuzur Rahman MR Gonzalez-José Rolando R Schüler-Faccini Lavinia L Bortolini Maria-Cátira MC Acuña-Alonzo Victor V Canizales-Quinteros Samuel S Gallo Carla C Poletti Giovanni G Rojas Winston W Rothhammer Francisco F Navarro Nicolas N Wang Sijia S Adhikari Kaustubh K Ruiz-Linares Andrés A
Communications biology 20230508 1
We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5 × 10<sup>-8</sup>) at 42 genome regions, nine of which have been previously reported. In follow-up analyses, 26 of the 33 novel regions replicate in East Asians, Europeans, or Africans, and one mouse homologous region influences craniofacial morphology in mic ...[more]
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