Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals.

ABSTRACT: Brain serotonergic (5-HT) signaling is posited to modulate neural responses to emotional stimuli. Dysfunction in 5-HT signaling is implicated in major depressive disorder (MDD), a disorder associated with significant disturbances in emotion processing. In MDD, recent evidence points to altered 5-HT₄ receptor (5-HT₄R) levels, a promising target for antidepressant treatment. However, how these alterations influence neural processing of emotions in MDD remains poorly understood. This is the first study to examine the association between 5-HT₄R binding and neural responses to emotions in patients with MDD and healthy controls. The study included one hundred and thirty-eight participants, comprising 88 outpatients with MDD from the NeuroPharm clinical trial (Cli

SUBMITTER: Sankar A 

PROVIDER: S-EPMC10175268 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature