Comprehensive Analysis to Reveal Amino Acid Metabolism-Associated Genes as a Prognostic Index in Gastric Cancer.

ABSTRACT:

Background

Amino acid metabolism (AAM) is related to tumor growth, prognosis, and therapeutic response. Tumor cells use more amino acids with less synthetic energy than normal cells for rapid proliferation. However, the possible significance of AAM-related genes in the tumor microenvironment (TME) is poorly understood.

Methods

Gastric cancer (GC) patients were classified into molecular subtypes by consensus clustering analysis using AAMs genes. AAM pattern, transcriptional patterns, prognosis, and TME in distinct molecular subtypes were systematically investigated. AAM gene score was built by least absolute shrinkage and selection operator (Lasso) regression.

Results

The study revealed that copy number variation (CNV) changes were prevalent in selected AAM-related gen

SUBMITTER: Zhao G 

PROVIDER: S-EPMC10195167 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature