Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

The upper tolerable intake level for vitamin D in the general population has been set at 4000 international units (IU) daily, but considerable uncertainty remains. We summarized reported harmful effects of a daily vitamin D supplement of 3200-4000 IU in trials lasting ≥ 6 months.

Methods

We performed a systematic review and meta-analysis of randomized controlled trials in several databases and identified 22 trials reporting safety data. Parameters of calcium metabolism, falls, hospitalization, and mortality were assessed.

Results

The selected trials comprised a total number of 12,952 participants. All trials used supplemental vitamin D₃. The relative risk (RR) of hypercalcemia in the vitamin D vs. control arm was 2.21 (95%CI: 1.26-3.87; 10 studies),

SUBMITTER: Zittermann A 

PROVIDER: S-EPMC10195747 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature