Investigating immune profile by CyTOF in individuals with long-standing type 1 diabetes.

ABSTRACT: Type 1 diabetes (T1D) is an autoimmune disease caused by T-cell mediated destruction of pancreatic beta cells. Eosinophils are found in pancreatic tissue from individuals with T1D. Eosinophilic suppression of T cells is dependent of the protein galectin-10. Little is known when it comes to the role of eosinophil granulocytes in type 1 diabetes. Here we show that individuals with long-standing T1D had lower levels of galectin-10^hi eosinophils and a subgroup of galectin-10^hi eosinophils were entirely absent in all T1D patients. In addition, 7% immature eosinophils were present in the circulation of T1D patients whereas 0.8% in healthy individuals. Furthermore, higher levels of CD4+CD8+ T cells and Th17 cells were observed in patients with T1D. Blood samples from 12 adul

SUBMITTER: Larsson H 

PROVIDER: S-EPMC10199897 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature