Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium: An Age-Stratified Study.

ABSTRACT:

Introduction

Rocuronium intravenous pain is common in induction of general anesthesia. The aim of our study was to determine the median effective dose (ED₅₀) of prophylactic intravenous remifentanil for the prevention of rocuronium injection pain and to explore the effect of age on the ED₅₀.

Methods

Eighty-nine adult patients undergoing elective general anesthesia, ASA I or II, regardless of gender or weight, were stratified according to age: group R1 18-44 years, group R2 45-59 years, and group R3 60-80 years. The initial dose of prophylactic remifentanil before rocuronium injection was set at 1 μg/kg lean body weight (LBW). The remifentanil doses were adjusted according to the degree of injection pain using the Dixon sequential method, with a ratio of

SUBMITTER: Yan S 

PROVIDER: S-EPMC10199981 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature