Natural History of Malaria Infections During Early Childhood in Twins.

ABSTRACT:

Background

The frequency and clinical presentation of malaria infections show marked heterogeneity in epidemiological studies. However, deeper understanding of this variability is hampered by the difficulty in quantifying all relevant factors. Here, we report the history of malaria infections in twins, who are exposed to the same in utero milieu, share genetic factors, and are similarly exposed to vectors.

Methods

Data were obtained from a Malian longitudinal birth cohort. Samples from 25 twin pairs were examined for malaria infection and antibody responses. Bayesian models were developed for the number of infections during follow-up.

Results

In 16 of 25 pairs, both children were infected and often developed symptoms. In 8 of 25 pairs, only 1 twin was infected, but us

SUBMITTER: Goncalves BP 

PROVIDER: S-EPMC10202434 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature