Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections.

ABSTRACT: The increasing incidence of infected skin wounds poses a major challenge in clinical practice, especially when conventional antibiotic therapy fails. In this context, bacteriophages emerged as promising alternatives for the treatment of antibiotic-resistant bacteria. However, clinical implementation remains hampered by the lack of efficient delivery approaches to infected wound tissue. In this study, bacteriophage-loaded electrospun fiber mats were successfully developed as next-generation wound dressings for the treatment of infected wounds. We employed a coaxial electrospinning approach, creating fibers with a protective polymer shell, enveloping bacteriophages in the core while maintaining their antimicrobial activity. The novel fibers exhibited a reproducible fiber diameter range and m

SUBMITTER: Kielholz T 

PROVIDER: S-EPMC10205809 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature