Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta-analysis of studies using brain amyloid beta status for case definition.

ABSTRACT:

Introduction

We performed a systematic review and meta-analysis of the association between retinal imaging parameters and Alzheimer's disease (AD).

Methods

PubMed, EMBASE, and Scopus were systematically searched for prospective and observational studies. Included studies had AD case definition based on brain amyloid beta (Aβ) status. Study quality assessment was performed. Random-effects meta-analyses of standardized mean difference, correlation, and diagnostic accuracy were conducted.

Results

Thirty-eight studies were included. There was weak evidence of peripapillary retinal nerve fiber layer thinning on optical coherence tomography (OCT) (p = 0.14, 11 studies, n = 828), increased foveal avascular zone area on OCT-angiography (p = 0.18, four stu

SUBMITTER: Ashraf G 

PROVIDER: S-EPMC10210353 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature