Unknown

Dataset Information

0

Modulation of innate immunity in airway epithelium for host-directed therapy.


ABSTRACT: Innate immunity of the mucosal surfaces provides the first-line defense from invading pathogens and pollutants conferring protection from the external environment. Innate immune system of the airway epithelium consists of several components including the mucus layer, mucociliary clearance of beating cilia, production of host defense peptides, epithelial barrier integrity provided by tight and adherens junctions, pathogen recognition receptors, receptors for chemokines and cytokines, production of reactive oxygen species, and autophagy. Therefore, multiple components interplay with each other for efficient protection from pathogens that still can subvert host innate immune defenses. Hence, the modulation of innate immune responses with different inducers to boost host endogenous front-line defenses in the lung epithelium to fend off pathogens and to enhance epithelial innate immune responses in the immunocompromised individuals is of interest for host-directed therapy. Herein, we reviewed possibilities of modulation innate immune responses in the airway epithelium for host-directed therapy presenting an alternative approach to standard antibiotics.

SUBMITTER: Myszor IT 

PROVIDER: S-EPMC10213533 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Modulation of innate immunity in airway epithelium for host-directed therapy.

Myszor Iwona T IT   Gudmundsson Gudmundur Hrafn GH  

Frontiers in immunology 20230512


Innate immunity of the mucosal surfaces provides the first-line defense from invading pathogens and pollutants conferring protection from the external environment. Innate immune system of the airway epithelium consists of several components including the mucus layer, mucociliary clearance of beating cilia, production of host defense peptides, epithelial barrier integrity provided by tight and adherens junctions, pathogen recognition receptors, receptors for chemokines and cytokines, production o  ...[more]

Similar Datasets

| S-EPMC8662554 | biostudies-literature
| S-EPMC3175551 | biostudies-literature
| S-EPMC7506214 | biostudies-literature
| S-EPMC7581375 | biostudies-literature
| S-EPMC7227448 | biostudies-literature
| S-EPMC7168302 | biostudies-literature
2010-04-30 | E-GEOD-19206 | biostudies-arrayexpress
| S-EPMC7482289 | biostudies-literature
| S-EPMC7163997 | biostudies-literature
| S-EPMC5965685 | biostudies-literature