The Diagnostic Potential of RNA Aptamers against the NS1 Protein of Dengue Virus Serotype 2.

ABSTRACT: Dengue infection, caused by the dengue virus, is a global threat which requires immediate attention and appropriate disease management. The current diagnosis of dengue infection is largely based on viral isolation, RT-PCR and serology-based detection, which are time-consuming and expensive, and require trained personnel. For early diagnosis of dengue, the direct detection of a dengue antigenic target is efficacious, and one such target is NS1. NS1-based detection is primarily antibody-centric and is beset by drawbacks pertaining to antibodies such as the high cost of synthesis and large batch-to-batch variation. Aptamers are potential surrogates of antibodies and are much cheaper, without exhibiting batch-to-batch variation. Given these advantages, we sought to isolate RNA aptamers against

SUBMITTER: Thevendran R 

PROVIDER: S-EPMC10215423 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature